Entelechy Ventures is a San Francisco Bay Area–based venture firm investing in frontier tech, AI cybersecurity, and AI-native systems of record. Founded by Monique Barbanson, the firm backs early-stage companies solving hard infrastructure problems in deploying AI, writing checks at seed through Series B and operating single-deal SPVs for accredited investors seeking exposure to pre-IPO allocations. Barbanson built products at Microsoft, Affirm, and Fastly and was part of a founding team at a Carnegie Mellon AI spinoff before moving into venture full-time. Entelechy emphasizes backing founding teams that include women, citing performance data from First Round Capital and BCG showing stronger returns and revenue efficiency at women-led startups.

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